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15 new interdisciplinary and exploratory research projects

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At the beginning of the year, the University of Bordeaux launched the 2nd edition of its call for projects aimed at stimulating interdisciplinary approaches in new fields of research to provide answers to the complex questions facing society. Of the 77 eligible projects, 15 were selected.

Photo : Interdisciplinary and exploratory research projects projects are small consortia of 2 to 4 researchers and their teams. © Gautier Dufau - University of Bordeaux
Interdisciplinary and exploratory research projects projects are small consortia of 2 to 4 researchers and their teams. © Gautier Dufau - University of Bordeaux

In order to overcome scientific and technological barriers and respond to major societal challenges requiring the contribution of different disciplines, the University of Bordeaux launched an annual call for interdisciplinary and exploratory research projects last year.

The second call was launched at the beginning of 2024. The projects were then evaluated on the basis of feedback from the research departments and an ad hoc committee comprising members of the Research Commission. Based on these evaluations, the final selection was carried out by the members of the University of Bordeaux's Research Coordination Committee, which was chaired by the Vice-Presidents for Research, Innovation and International networks.
15 projects involving all 11 research departments were selected for 2024, out of the 77 eligible projects submitted. The total budget is 1 million euros, with funding ranging from 42,000 € to 85,000 € depending on the project.

Once again, the scientific community was faced with two imperatives. The first was to propose an exploratory project, i.e. one that was innovative, either in terms of its cross-disciplinary approach or in terms of the scientific question addressed by the consortium. The project must not have been funded or co-published on the same subject over the previous 3 years.

Nathalie Sans © Arthur Pequin

"In the same way as the 2023 edition, this call for projects has been a success. Our community was highly mobilised and submitted as many projects as last year, if not a few more. We now have 35 research projects on a wide range of themes that meet the university's strategic priority of interdisciplinarity. I'm delighted with all the synergies that have been created, and hope that they will lead to future national and international research projects that will have an impact beyond our campus."

Nathalie Sans, University of Bordeaux Vice-President for research

The second requirement was for the proposed projects to be at the crossroads of different scientific fields, to increase synergies between different scientific communities, and to encourage interdisciplinarity.

The notion of interdisciplinarity can be considered at the level of a laboratory, a team or a department. In this particular case, innovative interdisciplinary collaboration associated with a given scientific question was given priority. Priority was also given to projects designed by researchers from different departments in a recent move towards new collaboration.

The 2023 edition of the call supported 20 projects, selected from 71 eligible applications, with an increased budget and support from the National Research Institute for Agriculture, Food and the Environment.

A stepping stone to further funding

These interdisciplinary and exploratory research projects, which last 24 months, are small consortia of 2 to 4 researchers and their teams, working to answer a very specific research question. They are therefore different from the more general Major Research Programmes, which focus on a given theme and involve a larger number of scientists.

The aim is also for this funding, which is managed by the laboratories, to act as a stepping stone for the scientists, enabling them to respond to other national calls for projects from the French National Research Agency, European calls for projects under the Horizon Europe programme, or early-stage funding if the results show potential for innovation.

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The 15 winning interdisciplinary and exploratory research projects

CANLYS - Understanding the effects of candidalysin on host cell membranes at the molecular level

Description: applying biophysical tools to decipher the molecular mechanisms and interactions that govern the activity of the fungal toxin candidalysin.

Coordination:

  • Sofiane El Kirat Chatel, CNRS research fellow - Institute of Chemistry and Biology of Membranes and Nano-objects (CBMN, Bordeaux INP, CNRS and University of Bordeaux unit)
    Health sciences and technologies research department
  • Thierry Noël, University professor - Fundamental Microbiology
    and Pathogenicity laboratory (MFP, CNRS and University of Bordeaux unit)
    Biological and medical sciences research department

Cell-phon - Non-invasive multi-spectral opto-acoustic imaging of GHz nano-rheology in cells

Description: This project aims to non-invasively image the intra-nuclear mechanical properties of cells by probing them in situ. Acoustic waves of variable submicron wavelengths likely to interact with nuclear mechanical heterogeneities will be generated and optically detected.

Coordination:

  • Bertrand Audoin, University professor - Institute of Mechanical Engineering  (I2M, Arts et Métiers ParisTech, Bordeaux INP, CNRS and University of Bordeaux unit)
    Engineering and digital sciences research department
  • Marie-Christine Durrieu, Inserm research director - Institute of Chemistry and Biology of Membranes and Nano-objects (CBMN, Bordeaux INP, CNRS and University of Bordeaux unit)
    Health sciences and technologies research department
  • Stefan Dilhaire, University professor - Wave and Material Laboratory of Aquitaine (LOMA, CNRS and University of Bordeaux unit)
    Material and light sciences research department

COFFEE - A new organ-on-a-chip for the functional characterisation of sarcopenia

Description: create a new muscle-on-a-chip model by combining cell encapsulation technology and electrical stimulation; characterise it molecularly, structurally and functionally, including its contraction and bioimpedance; and use it to identify an early diagnostic marker for sarcopenia.

Coordination

  • Pauline Henrot, Associate professor and hospital practitioner - Cardio-thoracix Research Centre of Bordeaux (CRCTB - Inserm and University of Bordeaux unit)
    Health sciences and technologies research department
  • Gaëlle Recher, CNRS research fellow - Photonics, Numerical and
    Nanosciences Laboratory (LP2N - CNRS, IOGS and University of Bordeaux unit)
    Material and light sciences research department
  • Sylvie Renaud, University professor - Integration: from Materials
    to System Laboratory (IMS - Bordeaux INP, CNRS and University of Bordeaux unit)
    Engineering and digital sciences research department

EuroDef - Europe in the face of war

Description: The project is characterised by a twofold scientific challenge: firstly, to bring together researchers from a number of disciplines working on the theme of war within the framework of an observatory of armed conflict, which will produce analyses and expert reports on current issues; and secondly, to develop on this basis a research project on ‘Europe in the face of war'. Through the prism of the various disciplines involved (law, economics, political science, sociology), this project will study the strategic challenges facing Europe as war returns to its borders.

Coordination:

  • Anne-Marie Tournepiche, professeur d’université - Centre de recherche et documentation européennes et internationales (CRDEI – unité université de Bordeaux)
    Département Droits et transformations sociales
  • Jean Belin, maître de conférences – Bordeaux Sciences Économiques (BSE, unité CNRS, INRAE et université de Bordeaux)
    Département Sciences sociales des changements contemporains – CHANGES
  • Caroline Dufy, maîtresse de conférences à Sciences Po Bordeaux – Centre Émile Durkheim (CED, unité CNRS, Sciences Po Bordeaux et université de Bordeaux)
    Département Sciences sociales des changements contemporains – CHANGES
  • Adrien Shu, maître de conférences – Institut de recherche Montesquieu (IRM, unité université de Bordeaux)
    Département Droits et transformations sociales

FM-MOFs - Magnetic, frustrated metal-organic networks

Description: Combining the versatility of organic metal network chemistry with the richness of the physics of frustrated magnetisms to unlock new avenues of quantum research.

Coordination:

  • Corine Mathonière, University professor - Paul Pascal Research Centre (CRPP, CNRS and University of Bordeaux unit)
    Material and light sciences reserach department
  • Ludovic Jaubert, CNRS researcher - Wave and Material
    Laboratory of Aquitaine (LOMA, CNRS and University of Bordeaux unit)
    Material and light sciences research department

IVOMOC - Identification of vocal biomarkers of craving in addiction

Description: Identifying vocal biomarkers of craving in addiction to enable passive detection of the risk of relapse in everyday life, and paving the way for new therapeutic targets for digital interventions.

Coordination:

  • Fuschia Serre, University research engineer - Sleep, Addiction and Neuropsychiatry (SANPSY, CNRS and University of Bordeaux unit)
    Bordeaux Neurocampus
  • Jean-Luc Rouas, CNRS research fellow - Bordeaux Computer Science Research Laboratory (LaBRI, Bordeaux INP, CNRS and University of Bordeaux unit)
    Engineering and digital sciences research department

MOLOTAC - Multi-omics approach to elucidate the effect of endocrine disruptors on the rainbow trout holobiont at the larval stage

Description: Potential and proven endocrine disruptor effect on the rainbow trout holobiont at an early stage by characterising microbiota ontogeny and metabolite dynamics using complementary omics approaches.

Coordination:

  • Laure Bellec, Associate professor - Oceanic and Continental Environments and Paleoenvironments Laboratory (EPOC, Bordeaux INP, CNRS and University of Bordeaux unit)
    Environmental sciences research department
  • Nicolas Creusot, INRAE research fellow - Aquatic Ecosystems and Global Change (EABX, INRAE unit)
    Environmental sciences research department
  • Hélène Budzinski, CNRS research director - Oceanic and Continental Environments and Paleoenvironments Laboratory (EPOC, Bordeaux INP, CNRS and University of Bordeaux unit)
    Environmental sciences research department

NanoICD - Exploiting the synergies between natural and artificial nanoparticles to promote immunogenic cell death

Description: Nanomedicine has enormous potential for the future, but still faces a number of hurdles in terms of targeting and efficacy. Here, we combine the expertise of two leading Bordeaux laboratories by exploiting the properties of natural nanoparticles (such as viruses and pseudoparticles) and artificial inorganic nanoparticles to ultimately induce immunogenic cell death (ICD), a promising strategy in cancer therapy, for example.

Coordination: 

  • Harald Wodrich, Inserm research director - Fundamental Microbiology and Pathogenicity laboratory (MFP, CNRS and University of Bordeaux unit
    Biological and medical sciences research department
  • Fabienne Rayne, Associate professor - Fundamental Microbiology and Pathogenicity laboratory (MFP, CNRS and University of Bordeaux unit
    Biological and medical sciences research department
  • Stéphane Mornet, CNRS research director - Institute for solid state
    chemistry Bordeaux (ICMCB - CNRS and University of Bordeaux unit)
    Material and light sciences research department

NANOLEAF - Revealing hydraulic dysfunctions in leaves during drought using high-resolution imaging techniques

Description: Deciphering water stress thresholds and the mechanisms associated with hydraulic failure by coupling X-ray microcomputed tomography and optical nanosensors on several crop and tree species.

Coordination:

  • Sylvain Delzon, INRAE research director - Biodiversity, Genes and Communities laboratory (BIOGECO, INRAE and University of Bordeaux unit)
    Environmental sciences reaserch department
  • Laurent Cognet, CNRS research director - Photonics, Numerical and
    Nanosciences laboratory (LP2N, CNRS, IOGS and University of Bordeaux unit)
    Material and light sciences research department

ORACLE - An interdisciplinary approach to the simulation of processions and water management in sacred practices at Delphi

Description: The ORACLE project aims to advance our understanding of worship practices at the oracular sanctuary of Apollo at Delphi through an interdisciplinary approach involving 3 departments at the University of Bordeaux. This interdisciplinary approach opens up new methodological and analytical perspectives for the simulation of physical phenomena that will be able to renew our understanding of the functioning of the oracular space and the experiences of pilgrims.

Coordination:

  • Delphine Lacanette, Professor at Bordeaux INP - Mechanics and Engineering Institute of Bordeaux (I2M, Arts et métiers ParisTech, Bordeaux INP, CNRS and University of Bordeaux unit)
    Engineering and digital sciences research department
  • Marie Beurton-Aimar, Associate professor - Bordeaux Computer Science Research Laboratory (LaBRI, Bordeaux INP, CNRS and University of Bordeaux unit)
    Engineering and digital sciences research department 
  • Aurélie Mounier, CNRS research engineer - Achéosciences Bordeaux: matériaux, temps images, sociétés (CNRS and University Bordeaux Montaigne unit)
    Archaeological sciences research department
  • Xavier Granier, Professor at IOGS - Photonics, Numerical and Nanosciences Laboratory (LP2N, a CNRS, IOGS and University of Bordeaux unit)
    Material and light sciences research department 
  • Colette Siriex, professeur d’université - Institut de mécanique et d’ingénierie de Bordeaux (I2M, unité Arts et métiers ParisTech, Bordeaux INP, CNRS et université de Bordeaux)
    Département Sciences de l’ingénierie et du numérique (SIN)

PaléEAUX - Changes in climate and deep water circulation in the Gironde region over the last 40 millennia using isotope analysis of aquifers

Description: The aim of this collaboration is to study the palaeorecharge of aquifers in the North Aquitaine basin that are used for drinking water, and to deduce palaeoclimatic data using trace-scale isotope analysis (18O, 2H, 14C, rare gases).

Coordination:

  • Michel Franceschi, Associate professor at Bordeaux INP - Oceanic and Continental Environments and Paleoenvironments Laboratory (EPOC, Bordeaux INP unit, CNRS and University of Bordeaux)
    Environmental sciences research department
  • Denis Horlait, CNRS research fellow - Laboratory of physics of the two infinities of Bordeaux (LP2IB, CNRS and University of Bordeaux unit)
    Material and lights sciences research department 
  • Pascal Bertran, INRAP research engineer - From Prehistory to Present Time: Culture, Environment and Anthropology Laboratory (PACEA, Ministry of Culture, CNRS and University of Bordeaux unit)
    Archaeological sciences research department

PhiloNeuro - The impact of philosophical reflection on current neurosciences

Description: Although the interweaving of neurosciences and philosophy has often been described as a paradigmatic success story of interdisciplinary integration, no work to date has accurately measured the impact of philosophical reflection on neurosciences. This project aims to fill this gap by mobilising a wide range of analytical tools, and to open up new avenues as to how philosophy might be useful to neurosciences in the future, in the Bordeaux area and beyond.

Coordination:

  • Thomas Pradeu, CNRS research director - Immunology from
    Concept and Experiments
    to Translation (Immunoconcept, CNRS, Inserm and University of Bordeaux unit)
    Biological and medical sciences research department
  • Serge Ahmed, CNRS research director - Aquitaine Institute of Cognitive and Integrative Neuroscience (INCIA, CNRS and University of Bordeaux unit)
    Bordeaux Neurocampus
  • Thomas Boraud, CNRS research director - Institute of Neurodegenerative Diseases (IMN, CNRS and University of Bordeaux unit)
    Bordeaux Neurocampus
  • Nora Abrous, Inserm research director - Neurocentre Magendie (Inserm and University of Bordeaux unit)
    Bordeaux Neurocampus 
  • Aline Desmedt, University professor - Neurocentre Magendie (Inserm and University of Bordeaux unit)
    Bordeaux Neurocampus 

SWEETHEALTH - Stevia rebaudiana: from sustainable production to anti-inflammatory and anti-cancer properties

Description: Agro-ecological transition and human health. Stevia rebaudiana is a plant species known for accumulating steviol glycosides (SG) in its leaves, which are used as a natural sweetener. Local, sustainable production of this species in south-west France has recently been developed through a complete chain from production to processing. This diversification species for farmers, produced using agro-ecology, also needs to be marketed in a variety of ways to ensure its long-term viability. This recently domesticated and relatively unselected species synthesises polyphenols in addition to SG, whose anti-inflammatory and anti-cancer/chemo-radio-protective effects have only been partially explored and will be assessed in this project.

Coordination:

  • Valérie Schurdi-Levraud, University professor - Fruit Biology and Pathology (BFP, INRAE and University of Bordeaux unit)
    Environmental sciences reaserch department
  • Sandrine Dabernat, University professor and hospital practitioner - Bordeaux Institute of Oncology (BRIC, Inserm and University of Bordeaux unit)
    Biological and medical sciences research department 
  • Stéphanie Krisa, Associate Professor - Oenology Laboratory (ŒNO - Bordeaux INP, BSA, Inrae and University of Bordeaux unit)
    Environmental sciences reasearch department

TEACH-MHE - Mental health literacy among future school teachers: an exploratory and experimental study

Description: Improving children's mental health is currently an important societal objective. School is a significant living environment for children and is therefore concerned by the issue of schoolchildren's mental health. This means that future teachers need to be aware of and trained in these issues, which is all the more important given that children's mental health has been little studied, if not neglected. Our study therefore deals with a controversial subject (e.g. autism, attention deficit with or without hyperactivity, bullying, depression, suicide risk) concerning this age group.
Mental health literacy is a recent theory defined as the ability to find, understand, evaluate and use information, knowledge and beliefs about mental health. A good level of mental health literacy makes it possible to identify signs of malaise and to be equipped to deal with any mental health problem.
The aim of our study is twofold: to provide a tool for measuring the mental health literacy levels of students intending to become school teachers; and to co-create an intervention for students intending to become school teachers, with a view to improving their level of children's mental health literacy.

Coordination:

  • Ilaria Montagni, Lecturer-researcher - Bordeaux Population Health research centre (BPH, Inserm and University of Bordeaux unit)
    Public health research department
  • Magali Boizumault, Associate professor - Laboratory of Culture,
    Education, Societies (LACES, University of Bordeaux unit)
    Behaviour, organisations and policy evaluation research department 
  • Marthe-Aline Jutand, Associate Professor - Culture and Dissemination of Knowledge Laboratory (CeDS, University of Bordeaux unit)
    Social sciences of contemporary changes research department
  • Stéphanie Constans, Associate professor - Laboratory of Psychology (LabPsy, University of Bordeaux unit)
    Behaviour, organisations and policy evaluation research department 

Therapoptosis - Targeting the DR5 death receptor for theranostic applications

Description: Targeting the DR5 receptor to counter tumour heterogeneity.

Coordination:

  • Clément Morgat, Associate professor and hospital practitioner - Aquitaine Institute of Cognitive and Integrative Neuroscience (INCIA, CNRS and University of Bordeaux unit)
    Bordeaux Neurocampus
  • Gilles Guichard, CNRS research director - Institute of Chemistry and Biology of Membranes and Nano-objects (CBMN, Bordeaux INP, CNRS and University of Bordeaux unit)
    Health sciences and technologies research department 
  • Majid Khatib, Inserm research director - Bordeaux Institute of Oncology (BRIC, Inserm and University of Bordeaux unit)
    Biological and medical sciences research department